Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults.
نویسندگان
چکیده
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منابع مشابه
DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue.
OBJECTIVE The human leukocyte antigen (HLA) DQB1*0602 allele is closely associated with narcolepsy, a neurologic disorder characterized by excessive daytime sleepiness, fragmented sleep, and shortened REM sleep latency. We evaluated whether DQB1*0602 was a novel marker of interindividual differences by determining its relationship to sleep homeostatic, sleepiness, and cognitive responses to bas...
متن کاملFaster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602.
HLA DQB1*0602 is found in most individuals with hypocretin-deficient narcolepsy, a disorder characterized by a severe disruption of sleep and wake. Population studies indicate that DQB1*0602 may also be associated with normal phenotypic variation of rapid eye movement (REM) sleep. Disruption of REM sleep has been linked to specific symptoms of insomnia. We here examine the relationship of sleep...
متن کاملHLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy.
Narcolepsy is considered a homogeneous clinical entity when excessive daytime sleepiness and cataplexy are present. Cataplexy is a polymorphic symptom that can be very mild and is thus subjectively defined. The Multiple Sleep Latency Test (MSLT) is widely used as a diagnostic test for narcolepsy. A short mean sleep latency and multiple sleep onset REM periods (SOREMPs) are typically observed in...
متن کاملNarcolepsy-cataplexy syndrome associated with DRB1*0806-DQB*0602 haplotype in a Caucasian patient.
Narcolepsy-Cataplexy (NC) is a neurological disorder associated with the human leukocyte antigen HLA DR2. This is a prerequisite for the disease in 95 to 98% of Caucasian patients. It has been demonstrated that the HLA DQB1*0602 allele is a better marker for narcolepsy than DRB1*1501 (DR2). We present a DR-negative and DQB1*0602-positive Caucasian Spanish patient with a very unusual genotype. A...
متن کاملUse of PCR with Sequence-specific Primers for High-Resolution Human Leukocyte Antigen Typing of Patients with Narcolepsy
BACKGROUND Narcolepsy is a neurologic disorder characterized by excessive daytime sleepiness, symptoms of abnormal rapid eye movement (REM) sleep, and a strong association with HLA-DRB1*1501, -DQA1*0102, and -DQB1*0602. Here, we investigated the clinico-physical characteristics of Korean patients with narcolepsy, their HLA types, and the clinical utility of high-resolution PCR with sequence-spe...
متن کاملNocturnal Sleep and Daytime Sleepiness in Normal Subjects with HLA - DQB 1 * 0602 NORMAL SUBJECTS
nism underlying narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and abnormal REM sleep, remains elusive, one of the susceptibility factor, HLADQB1*0602, has now been identified. Subjects homozygous or heterozygous for this HLA-DQB1 allele are at much greater risk of developing narcolepsy than subjects without this antigen. DNA sequencing studies, family studies and tr...
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ورودعنوان ژورنال:
- Lancet
دوره 351 9104 شماره
صفحات -
تاریخ انتشار 1998